Metabolomix+ : A Non-Invasive Personalized Nutritional Assessment with a video summary of your personalized results and recommendations from Dr. Bronner.
The Metabolomix+ is a unique combination of nutritional tests that provides an analysis of key nutritional biomarkers. A first morning void (FMV) urine collection, with optional add-on bloodspot finger stick and buccal swab, the Metabolomix+ nutritional test is a non-invasive, patient-friendly way to assess the functional need for antioxidants, B-vitamins, minerals, digestive support, fatty acids, and amino acids. Insights gained from the Metabolomix+ nutritional test allows clinicians to target nutritional therapies to meet the precise needs of their patients.
Metabolomix+ is one of the most comprehensive functional and nutritional assessments available. It is designed to help practitioners identify root causes of dysfunction and provide a systems-based approach to help patients overcome chronic conditions and live a healthier life.
The Metabolomix+ report offers:
- Nutrient recommendations for key vitamins, minerals, amino acids, fatty acids, and digestive support
- Functional pillars with a built-in scoring system to guide therapy around needs for methylation support, toxic exposures, mitochondrial dysfunction, fatty acid imbalances, and oxidative stress
- Interpretation-At-A-Glance pages for patient education
- Dynamic biochemical pathway charts for clearer understanding
What is a functional nutritional assessment?
Marked accumulation of organic acids in urine can signal a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect.
Enzymes that are responsible for metabolizing organic acids are vitamin and mineral dependent. With this, elevations in organic acids can reflect a functional need for these nutrients on a cellular and biochemical level, even despite normal serum levels.1-5 Recommendations for nutrient supplementation based on elevated organic acid results are generated using a literature-based proprietary algorithm.
Traditionally, urinary organic acid assessment has been used in neonatal/pediatric medicine to identify genetic inborn errors of metabolism, with severity depending on the degree and type of error.* In many cases of genetic inborn errors, the enzymatic defect may be compensated for by high doses of specific vitamin and mineral cofactors and/or dietary interventions. Intervention with higher-dose nutrient cofactors may also be effective in cases of decreased enzyme activity due to causes other than frank inborn errors.
* Genova’s organic acid testing is not intended for the diagnosis of neonatal inborn errors of metabolism.
Which patients might benefit from functional nutritional testing?
Common clinical indications for testing include:
- Mood Disorders6,7
- Mitochondrial Dysfunction8
- Chronic Stress10
Several diseases are associated with abnormal organic acid, amino acid, and fatty acid levels such as depression, anxiety, cardiovascular disease, neurocognitive decline, diabetes, cancer, anorexia, and many others.12-15
About the Metabolomix+ Profile
The Metabolomix+ Profile report allows for easy interpretation and clinically actionable results. It includes a Suggested Supplement Schedule that provides personalized recommendations based on test results. The Interpretation-At-A-Glance section of the report provides facts related to nutrient function, causes and complications of their deficiencies, and dietary sources.
The Metabolomix+ Profile report categorizes results into several metabolic areas:
- Organic Acids (urine)
- Malabsorption and Dysbiosis Markers are metabolites produced by the gastrointestinal microbiome
- Cellular Energy & Mitochondrial Markers are biomarkers of carbohydrate and fatty acid metabolism, and the citric acid (Kreb’s) cycle
- Vitamin Markers are specific analytes used to assess functional levels of vitamin cofactors
- Neurotransmitter Metabolites are downstream byproducts of epinephrine, norepinephrine, serotonin and dopamine
- Toxin & Detoxification Markers relate to certain toxic metabolites and the body’s detoxification capacity
- NEW Oxalate Markers relate to kidney stone formation, oxidative stress and metabolic dysfunction
- Amino Acids (urine)
- Essential Amino Acids must be derived from dietary sources
- Nonessential Amino Acids are synthesized by the body
- Intermediary Metabolites are byproducts of amino acid metabolism
- Dietary Peptide Related Markers can indicate incomplete protein breakdown
- Oxidative Stress Markers (urine) include the oxidative damage markers lipid peroxides and 8-OHdG
- Essential and Metabolic Fatty Acids – Bloodspot (if selected as add-on profile)
- Omega 3 Fatty Acids are essential for brain function and cardiovascular health and are anti-inflammatory
- Omega 6 Fatty Acids are involved in the balance of inflammation
- Omega 9 Fatty Acids are important for brain growth, nerve cell myelin, and reducing inflammation
- Saturated Fatty Acids are involved in liproprotein metabolism and adipose tissue inflammation
- Monounsaturated Fats include omega 7 fats and unhealthy trans fats
- Delta-6 Desaturase Activity assesses efficiency of this enzyme to metabolize omega 6’s and omega 3’s
- Cardiovascular Risk includes specific ratios and the Omega 3 Index
- Nutrient and Toxic Elements – urine (if selected as add-on profile) assesses 20 toxic and 15 mineral elements
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