Thyroid Resistance Syndrome and Reverse T3

Thyroid Resistance Syndrome-RT3

Thyroid resistance syndrome is a result of the body converting T4 (Thyroxine) to a form of T3 (liothyronine) known as reverse T3. This can occur on its own or if a person has been on T4 containing medication like Synthroid or even one of the porcine glandular medications such as Armour thyroid. As long as T4 is coming into the body there is the ability for it to be converted to reverse T3 if the correct conditions exist.

Reverse T3 is completely inactive. The body has a built-in mechanism for the balance of T3 and RT3. Under various conditions, the body can shift the ratio of T3 to reverse T3 and an imbalance can occur. You can calculate the ratio of FT3 to RT3. A healthy ratio is greater than 20.

What happens if I make too much RT3?

It will become an issue. It binds to the T3 receptor sites. This, in turn, blocks the beneficial effects of T3 and the result is that you remain functionally hypothyroid and have many of the lingering symptoms even if your labs look normal. This can be very frustrating for many patients and they can suffer if this situation is not found and corrected. Many people who seem to chase their dosing of thyroid medication have thyroid resistance. The typical story I hear is " I began on one dose and have had to continually increase the dosing because I feel good for a few weeks and then the symptoms return." This continual need for dose increases is a sure sign of thyroid resistance syndrome.

As you can see T3 and rT3 look alike except for the fact that one iodine (I) molecule has been switched creating a mirror (isomer) image of T3. This form is completely inactive and also blocks receptors from being able to use circulating T3.

Please read more about this from top journals.

Thyroid hormone concentrations, disease, physical function, and mortality in elderly men

A study of the extrathyroidal conversion of thyroxine (T4) to 3,3',5-triiodothyronine (T3) in vitro

Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population

Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats.

Hypothyroidism and the Heart

Why Choose Integrative Health Solutions for Thyroid Resistance Syndrome-RT3?

Integrative Health Solutions and Dr. Bronner Handwerger NMD have been providing cutting-edge thyroid treatment to patients for 20 years. We have become the leading experts in Thyroid treatment in San Diego. Here are some of the reasons why you can trust the team at Integrative Health Solutions:

  • Advanced Technology:

    At Integrative Health Solutions, we are known for using advanced testings, which help in finding the underlying issues. We are always one step ahead using the most advanced technologies.

  • Qualified Professionals:

    Our leading doctors are experts in the field of endocrinology and thyroid conditions and treatments.

  • Thorough Approaches:

    Our solutions and approaches to treatment look at all aspects and look to balance and optimize the patient.